Larger studies are needed

Obstetric Pharmacokinetic Dosing Studies are Urgently Needed

Use of pharmacotherapy during pregnancy is common and increasing. Physiologic changes during pregnancy may significantly alter the overall systemic drug exposure, necessitating dose changes. A search of PubMed for pharmacokinetic clinical trials showed 494 publications during pregnancy out of 35,921 total pharmacokinetic published studies (1.29%), from the late 1960s through August 31, 2013. Cl...

What dynamic capabilities are needed in ERP activity?

Although many scholars have proposed all kinds of key successful factors (KSFs) for ERP activity to smoothly enhance the implementation of ERP, the KSFs are based too much on concept and protocol cannot help an enterprise to achieve this objective. Therefore, this research through qualitative interview method, integrating the KSFs and dynamic capability to set up a model so as to exhibit the ki...

Prospective, population based studies of cavernous malformations are needed.

Are haemophiliacs protected against cancer development? Prospective controlled studies are needed

We read with interest the recent article by Brüggemann and colleagues [1]. In a murine (B16F10 murine melanoma cell line) experimental study, the authors have demonstrated that congenital prothrombotic disorders, like factor V Leiden, ease the metastatic capacity of cancer, whereas congenital bleeding tendencies, like haemophilia A, impede metastasis. These results are in agreement with those p...

What Are Neutrons Needed For

If you want to see an object, you have to illuminate it. If you want to discern details of an object, you will have to illuminate it with "light" of a wavelength equal to or smaller than the distance between the object details you are interested in. For most solids (or condensed media), such details of interest to physicists (for example, lattice sites, liquids, colloids, plastics, polymer and ...